The film starts with a masked killer entering an apartment and murdering a young couple, Krish and Shruti one cold, rainy night in Coimbatore. Five years later, Deepak, the retired police inspector who lost his leg while investigating the case, receives a call from a friend. The friend's son is adamant on becoming a police officer. So, the friend sends his son to Deepak so Deepak can brainwash him into not joining the force since his parents feels it is too dangerous. When the son arrives, he asks Deepak to tell him how he became crippled. Deepak begins to narrate his story of the final case that robbed him of the job he loved.
During an exclusive tour, a power breakdown inside a secret prison known as the Death House sends two agents fighting through a labyrinth of horrors while being pursued by a ruthless army of roaming inmates. As they fight to escape, the agents push toward the lowest depths of the facility where they learn a supernatural group of evil beings are their only chance for survival.
莎拉(丹妮尔·帕娜贝克 Danielle Panabaker 饰)是一个单纯到有些天真的女孩,陷入了和有妇之夫泰瑞(安德鲁·霍华德 Andrew Howard 饰)的情感纠葛之中。然而,让莎拉没有想到的是,一天,泰瑞竟然在毫无征兆的情况下将她残忍的抛弃了。莎拉的同事露(妮可·拉里贝特 Nicole LaLiberte 饰)不忍心看到好友如此难过,于是把她带到酒吧买醉,在那里,两人邂逅了名为西蒙(迈克尔·斯达-大卫 Michael Stahl-David 饰)的男子。
让莎拉没有想到的是,看起来彬彬有礼风度翩翩的西蒙实际上是一个禽兽,他借着送醉酒的莎拉回家在莎拉的家门口将她强暴了。愤怒的露设计偷到了一把手枪,她要带着莎拉向两个男人寻仇。