在一所临海别墅里，住着Charlie（查理·辛 Charlie Sheen 饰）和Alan（乔恩·克莱尔 Jon Cryer 饰）兄弟俩，一个是花花公子作曲家，身边总有穿梭不断的美女；一个是离婚后被老婆赶出来的按摩师，只能寄居在哥哥家里。这两个单身汉的生活里还有一个小小的“好汉”——Alan的儿子Jake（安加斯·T·琼斯 Angus T. Jones 饰），每到周末，Alan就会从前妻家里把Jake接到这所单身汉别墅。
值得一提的是几个不时在兄弟俩生活中露一把脸的配角，让兄弟两个对女人产生阴影的魔鬼老妈，刻薄的前妻，拽得要死的清洁女佣，还有和Charlie春宵一夜之后就跟踪了他两三年的邻居Rose。
It was the age of Da Vinci and Michelangelo, of enlightened creativity and unparalleled intellectual achievement. But it was also the age of Machievelli, of rampant lawlessness, incessant war and unspeakable depravity. At the heart of the world order was the Vatican, the arbiter of conflicts between kingdoms and empires. And at the center of the Vatican was a man whose quest for power would propel him to seek the ultimate prize, the holy see of Rome. He was a man whose name would become synonymous with ruthlessness, and whose reign as pope would be remembered as the most infamous chapter of the history of the Catholic church -Rodrigo Borgia. His four children -Juan, the oldest, a prideful, lazy, unscrupulous sexual predator, Cesare, a young man torn between a faith that was not his calling and his dark violent nature, Lucretia, a young girl discovering the secret power that a women's sexuality holds...
